Vista Equipo: Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering

Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering

The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal gr...

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Autores Principales:	Abdal-Hay, A, Vanegas Peralta, Pablo Fernando
Formato:	Artículos
Publicado:	ELSEVIER 2018
Materias:	Chain conformation Hydroxyapatite Nano-structures Nylon 6 Surface treatments
Acceso en línea:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903597508&doi=10.1016%2fj.cej.2014.05.118&partnerID=40&md5=982da8391532061051f0fb405e16f92b http://dspace.ucuenca.edu.ec/handle/123456789/22055
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spelling	oai:localhost:123456789-220552018-02-17T11:26:58Z Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering Abdal-Hay, A Vanegas Peralta, Pablo Fernando Chain conformation Hydroxyapatite Nano-structures Nylon 6 Surface treatments The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal growth of HA nanoplates from a colloidal solution onto the surface of nylon (N6) nanofibers was carried out via a hydrothermal approach. The factors affecting the scaffold's morphology, macrostructure and the interfacial bonding between the constituents as well as the influence of crystal size were characterized and well elucidated. The results revealed that the deposition of dense and thick uniform nanoplates was perpendicular and nucleated in a parallel configuration onto the longitudinal axes of the individual nanofibers during the treatment process. The sizes of the nanoplates, which are strongly dependent on the reaction time, were 30 and 95. nm in length, with thicknesses of 17-19. nm, after 2 and 3. h respectively. The nanoplates improve the mechanical properties of the HA/N6 biocomposite scaffolds. The surface properties of the fabricated scaffolds appeared to have a greater effect on the early stages of osteoblast behavior (cell attachment and proliferation). The cells attached, grew and proliferated faster on culture-coated scaffolds in comparison with the pristine ones. Our results indicate that the treated scaffolds fulfill the basic requirements of bone tissue engineering scaffolds, and have the potential to be applied in orthopedic and reconstructive surgeries. © 2014 Elsevier B.V. 2018-01-11T21:21:51Z 2018-01-11T21:21:51Z 2014-10-15 info:eu-repo/semantics/Article 13858947 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903597508&doi=10.1016%2fj.cej.2014.05.118&partnerID=40&md5=982da8391532061051f0fb405e16f92b http://dspace.ucuenca.edu.ec/handle/123456789/22055 10.1016/j.cej.2014.05.118 en_US instname:Universidad de Cuenca reponame:Repositorio Digital de la Universidad de Cuenca info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/3.0/ec/ ELSEVIER Chemical Engineering Journal info:eu-repo/date/embargoEnd/2022-01-01 0:00
institution	UCUENCA
collection	Repositorio UCUENCA
universidades	UCUENCA
language
format	Artículos
topic	Chain conformation Hydroxyapatite Nano-structures Nylon 6 Surface treatments
spellingShingle	Chain conformation Hydroxyapatite Nano-structures Nylon 6 Surface treatments Abdal-Hay, A Vanegas Peralta, Pablo Fernando Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
description	The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal growth of HA nanoplates from a colloidal solution onto the surface of nylon (N6) nanofibers was carried out via a hydrothermal approach. The factors affecting the scaffold's morphology, macrostructure and the interfacial bonding between the constituents as well as the influence of crystal size were characterized and well elucidated. The results revealed that the deposition of dense and thick uniform nanoplates was perpendicular and nucleated in a parallel configuration onto the longitudinal axes of the individual nanofibers during the treatment process. The sizes of the nanoplates, which are strongly dependent on the reaction time, were 30 and 95. nm in length, with thicknesses of 17-19. nm, after 2 and 3. h respectively. The nanoplates improve the mechanical properties of the HA/N6 biocomposite scaffolds. The surface properties of the fabricated scaffolds appeared to have a greater effect on the early stages of osteoblast behavior (cell attachment and proliferation). The cells attached, grew and proliferated faster on culture-coated scaffolds in comparison with the pristine ones. Our results indicate that the treated scaffolds fulfill the basic requirements of bone tissue engineering scaffolds, and have the potential to be applied in orthopedic and reconstructive surgeries. © 2014 Elsevier B.V.
author	Abdal-Hay, A Vanegas Peralta, Pablo Fernando
author_facet	Abdal-Hay, A Vanegas Peralta, Pablo Fernando
author_sort	Abdal-Hay, A
title	Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_short	Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_full	Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_fullStr	Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_full_unstemmed	Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_sort	preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
publisher	ELSEVIER
publishDate	2018
url	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903597508&doi=10.1016%2fj.cej.2014.05.118&partnerID=40&md5=982da8391532061051f0fb405e16f92b http://dspace.ucuenca.edu.ec/handle/123456789/22055
_version_	1635523470809890816
score	11,871979

Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering

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