Imagen de Portada

Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity

The human opportunistic fungus Candida albicans causes a wide range of infections including superficial, deep-seated and disseminated candidiasis. Its ability to switch from yeast to hyphal growth has been associated with the conversion from a colonizing to an invasive stage. The Eed1 (Epithelial...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor Principal: Alb?n Proa?o
Otros Autores: Hube, Bernhard
Formato: Tesis de Maestría
Lenguaje:deu
Publicado: ALEMANIA / Facultad: Medicina-Friedrich-Sciller-Univerit?t Jena / 2013 2014
Materias:
CANDIDA ALBICANS
MORFOG?NESIS
EED1
RANGE
Acceso en línea:http://repositorio.educacionsuperior.gob.ec//handle/28000/1209
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:localhost:28000-1209
recordtype dspace
spelling oai:localhost:28000-12092017-02-21T19:16:25Z Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity Alb?n Proa?o Hube, Bernhard Kurzai, Oliver CANDIDA ALBICANS MORFOG?NESIS EED1 RANGE The human opportunistic fungus Candida albicans causes a wide range of infections including superficial, deep-seated and disseminated candidiasis. Its ability to switch from yeast to hyphal growth has been associated with the conversion from a colonizing to an invasive stage. The Eed1 (Epithelial Escape and Dissemination 1) protein is necessary for the maintenance of hyphal growth after a tightly regulated process has initiated the yeast-to-hyphal transition. The production of Quorum Sensing Molecules (QSM) is a mechanism modulating morphology in C. albicans populations observed In a cell density-dependent manner. The QSM farnesol inhibits germ tube formation through the repression of the cAMP- PKA signaling pathway [2], and recently, it has been shown that it can modulate morphology in preformed hyphal cells to induce their transition into yeast growth [3]. Based on the observation that morphology of an EED1 homozygous mutant strain (eed1?) was strongly affected by cell density, a putative role of EED1 in quorum sensing mechanisms has been proposed. To contribute to the elucidation of the exact role of EED1 in C. albicans filamentation, sequential deletion mutants of the gene were evaluated in vitro under different hypha-inducing conditions to i) assess the contribution of the different regions of the gene in its function and ii) study the potential role of EED1 in the response of C. albicans to quorum sensing with a focus on farnesol 2014-06-24T16:32:35Z 2014-06-24T16:32:35Z 2013-10-25 masterThesis Alb?n Proa?o, Mar?a Cristina. (2013). Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity.ALEMANIA / Facultad: Medicina-Friedrich-Sciller-Univerit?t Jena. 60 p. http://repositorio.educacionsuperior.gob.ec//handle/28000/1209 deu openAccess http://creativecommons.org/licenses/by-nc-sa/3.0/ec/ 60 p. ALEMANIA / Facultad: Medicina-Friedrich-Sciller-Univerit?t Jena / 2013
institution SENESCYT
collection Repositorio SENESCYT
biblioteca Biblioteca Senescyt
language deu
format Tesis de Maestría
topic CANDIDA ALBICANS
MORFOG?NESIS
EED1
RANGE
spellingShingle CANDIDA ALBICANS
MORFOG?NESIS
EED1
RANGE
Alb?n Proa?o
Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
description The human opportunistic fungus Candida albicans causes a wide range of infections including superficial, deep-seated and disseminated candidiasis. Its ability to switch from yeast to hyphal growth has been associated with the conversion from a colonizing to an invasive stage. The Eed1 (Epithelial Escape and Dissemination 1) protein is necessary for the maintenance of hyphal growth after a tightly regulated process has initiated the yeast-to-hyphal transition. The production of Quorum Sensing Molecules (QSM) is a mechanism modulating morphology in C. albicans populations observed In a cell density-dependent manner. The QSM farnesol inhibits germ tube formation through the repression of the cAMP- PKA signaling pathway [2], and recently, it has been shown that it can modulate morphology in preformed hyphal cells to induce their transition into yeast growth [3]. Based on the observation that morphology of an EED1 homozygous mutant strain (eed1?) was strongly affected by cell density, a putative role of EED1 in quorum sensing mechanisms has been proposed. To contribute to the elucidation of the exact role of EED1 in C. albicans filamentation, sequential deletion mutants of the gene were evaluated in vitro under different hypha-inducing conditions to i) assess the contribution of the different regions of the gene in its function and ii) study the potential role of EED1 in the response of C. albicans to quorum sensing with a focus on farnesol
author2 Hube, Bernhard
author_facet Hube, Bernhard
Alb?n Proa?o
author Alb?n Proa?o
author_sort Alb?n Proa?o
title Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
title_short Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
title_full Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
title_fullStr Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
title_full_unstemmed Role of Candida albicans Eed1 protein in morphogenesis and pathogenicity
title_sort role of candida albicans eed1 protein in morphogenesis and pathogenicity
publisher ALEMANIA / Facultad: Medicina-Friedrich-Sciller-Univerit?t Jena / 2013
publishDate 2014
url http://repositorio.educacionsuperior.gob.ec//handle/28000/1209
_version_ 1634994994568757248
score 11,871979

Ejemplares similares