Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering

The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal gr...

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Main Author: Abdal-hay, Abdalla
Format: Artículos
Language:eng
Published: 2016
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Online Access:http://repositorio.educacionsuperior.gob.ec/handle/28000/2609
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spelling oai:localhost:28000-26092017-04-11T14:57:42Z Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering Abdal-hay, Abdalla NANO-STRUCTURES CHAIN CONFORMATION SURFACE TREATMENTS NYLON 6 The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal growth of HA nanoplates from a colloidal solution onto the surface of nylon (N6) nanofibers was carried out via a hydrothermal approach. The factors affecting the scaffold?s morphology, macrostructure and the interfacial bonding between the constituents as well as the influence of crystal size were characterized and well elucidated. The results revealed that the deposition of dense and thick uniform nanoplates was perpendicular and nucleated in a parallel configuration onto the longitudinal axes of the individual nanofibers during the treatment process. The sizes of the nanoplates, which are strongly dependent on the reaction time, were 30 and 95 nm in length, with thicknesses of 17?19 nm, after 2 and 3 h respectively. The nanoplates improve the mechanical properties of the HA/N6 biocomposite scaffolds. The surface properties of the fabricated scaffolds appeared to have a greater effect on the early stages of osteoblast behavior (cell attachment and proliferation). The cells attached, grew and proliferated faster on culture-coated scaffolds in comparison with the pristine ones. Our results indicate that the treated scaffolds fulfill the basic requirements of bone tissue engineering scaffolds, and have the potential to be applied in orthopedic and reconstructive surgeries. Universidad De Cuenca http://www.scopus.com/record/display.uri?eid=2-s2.0-84903597508&origin=resultslist&sort=plf-f&src=s&st1=Preparation+and+characterization+of+vertically+arrayed+hydroxyapatite+nanoplates+on+electrospun+nanofibers+for+bone&st2=&sid=202F81DCC604872D95B7BC7744ABE72F.CnvicAmOODVwpVrjSeqQ%3a790&sot=b&sdt=b&sl=130&s=TITLE-ABS-KEY%28Preparation+and+characterization+of+vertically+arrayed+hydroxyapatite+nanoplates+on+electrospun+nanofibers+for+bone%29&relpos=1&citeCnt=9&searchTerm= 2016-10-28T19:59:13Z 2016-10-28T19:59:13Z 2014 article Abdal-hay,Abdalla. et al. (2014). Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering. Chemical Engineering Journal. Vol 254. pp. 612?622. 1385-8947 http://repositorio.educacionsuperior.gob.ec/handle/28000/2609 eng restrictedAccess pp. 612?622.
institution SENESCYT
collection Repositorio SENESCYT
biblioteca Biblioteca Senescyt
language eng
format Artículos
topic NANO-STRUCTURES
CHAIN CONFORMATION
SURFACE TREATMENTS
NYLON 6
spellingShingle NANO-STRUCTURES
CHAIN CONFORMATION
SURFACE TREATMENTS
NYLON 6
Abdal-hay, Abdalla
Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
description The aim of this study is to develop a facile and an efficient approach for providing the electrospun nanofibers scaffold with a vertically well-aligned and homogeneous distribution of hydroxyapatite (HA) nanoplates that coat the scaffold while maintaining its fibrous and porous structure. Crystal growth of HA nanoplates from a colloidal solution onto the surface of nylon (N6) nanofibers was carried out via a hydrothermal approach. The factors affecting the scaffold?s morphology, macrostructure and the interfacial bonding between the constituents as well as the influence of crystal size were characterized and well elucidated. The results revealed that the deposition of dense and thick uniform nanoplates was perpendicular and nucleated in a parallel configuration onto the longitudinal axes of the individual nanofibers during the treatment process. The sizes of the nanoplates, which are strongly dependent on the reaction time, were 30 and 95 nm in length, with thicknesses of 17?19 nm, after 2 and 3 h respectively. The nanoplates improve the mechanical properties of the HA/N6 biocomposite scaffolds. The surface properties of the fabricated scaffolds appeared to have a greater effect on the early stages of osteoblast behavior (cell attachment and proliferation). The cells attached, grew and proliferated faster on culture-coated scaffolds in comparison with the pristine ones. Our results indicate that the treated scaffolds fulfill the basic requirements of bone tissue engineering scaffolds, and have the potential to be applied in orthopedic and reconstructive surgeries.
author Abdal-hay, Abdalla
author_facet Abdal-hay, Abdalla
author_sort Abdal-hay, Abdalla
title Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_short Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_full Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_fullStr Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_full_unstemmed Preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
title_sort preparation and characterization of vertically arrayed hydroxyapatite nanoplates on electrospun nanofibers for bone tissue engineering
publishDate 2016
url http://repositorio.educacionsuperior.gob.ec/handle/28000/2609
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score 11,871979