Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery
Chronic pesticide poisoning is difficult to detect. We sought to develop a low-cost test battery for settings such as Ecuador’s floriculture industry. First we had to develop a case definition; as with all occupational diseases a case had to have both sufficient effective dose and associated health...
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W.S. Maney & Son
2013
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ir-10644-32902016-04-04T16:42:38Z Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery Breilh, Jaime Pagliccia, Nino Yassi, Annalee CONTAMINACIÓN POR PLAGUICIDAS FLORICULTURA TOXICOLOGÍA DE PLAGUICIDAS PRUEBAS DE TOXICIDAD TOXICOLOGÍA EXPERIMENTAL NEUROBEHAVIOURAL EVALUATION SYSTEM, NES2 ENVIRONMENTAL STRESSORS Chronic pesticide poisoning is difficult to detect. We sought to develop a low-cost test battery for settings such as Ecuador’s floriculture industry. First we had to develop a case definition; as with all occupational diseases a case had to have both sufficient effective dose and associated health effects. For the former, using canonical discriminant analysis, we found that adding measures of protection and overall environmental stressors to occupational category and duration of exposure was useful. For the latter, factor analysis suggested three distinct manifestations of pesticide poisoning. We then determined sensitivity and specificity of various combinations of symptoms and simple neurotoxicity tests from the Pentox questionnaire, and found that doing so increased sensitivity and specificity compared to use of acethylcholinesterase alone – the current screening standard. While sensitivity and specificity varied with different case definitions, our results support the development of a low-cost test battery for screening in such settings. 2013-07-01T08:01:31Z 2013-07-01T08:01:31Z 2012 article Breilh, Jaime; Pagliccia, Nino y Yassi, Annalee. Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery. International Journal of Occupational and Environmental Health, 2012, 18(1): 7-21. http://hdl.handle.net/10644/3290 eng openAccess http://creativecommons.org/licenses/by-nc-sa/3.0/ec/ application/pdf ECUADOR CAYAMBE REGIÓN ANDINA W.S. Maney & Son |
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CONTAMINACIÓN POR PLAGUICIDAS FLORICULTURA TOXICOLOGÍA DE PLAGUICIDAS PRUEBAS DE TOXICIDAD TOXICOLOGÍA EXPERIMENTAL NEUROBEHAVIOURAL EVALUATION SYSTEM, NES2 ENVIRONMENTAL STRESSORS |
| spellingShingle |
CONTAMINACIÓN POR PLAGUICIDAS FLORICULTURA TOXICOLOGÍA DE PLAGUICIDAS PRUEBAS DE TOXICIDAD TOXICOLOGÍA EXPERIMENTAL NEUROBEHAVIOURAL EVALUATION SYSTEM, NES2 ENVIRONMENTAL STRESSORS Breilh, Jaime Pagliccia, Nino Yassi, Annalee Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| description |
Chronic pesticide poisoning is difficult to detect. We sought to develop a low-cost test battery for settings such as Ecuador’s floriculture industry. First we had to develop a case definition; as with all occupational diseases a case had to have both sufficient effective dose and associated health effects. For the former, using canonical discriminant analysis, we found that adding measures of protection and overall environmental stressors to occupational category and duration of exposure was useful. For the latter, factor analysis suggested three distinct manifestations of pesticide poisoning. We then determined sensitivity and specificity of various combinations of symptoms and simple neurotoxicity tests from the Pentox questionnaire, and found that doing so increased sensitivity and specificity compared to use of acethylcholinesterase alone – the current screening standard. While sensitivity and specificity varied with different case definitions, our results support the development of a low-cost test battery for screening in such settings. |
| author |
Breilh, Jaime Pagliccia, Nino Yassi, Annalee |
| author_facet |
Breilh, Jaime Pagliccia, Nino Yassi, Annalee |
| author_sort |
Breilh, Jaime |
| title |
Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| title_short |
Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| title_full |
Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| title_fullStr |
Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| title_full_unstemmed |
Chronic pesticide poisoning from persistent low-dose exposures in Ecuadorean floriculture workers: toward validating a low-cost test battery |
| title_sort |
chronic pesticide poisoning from persistent low-dose exposures in ecuadorean floriculture workers: toward validating a low-cost test battery |
| publisher |
W.S. Maney & Son |
| publishDate |
2013 |
| url |
http://hdl.handle.net/10644/3290 |
| _version_ |
1634935865139527680 |
| score |
11,871979 |